![]() ![]() During the second phase, a latent infection is normally established in these activated T cells, although some activated CD4 + and CD8 + T cells may undergo a lytic infection ( Baigent et al. Temporal immunosuppression of the humoral immune responses is often one of the consequences of the lytic infection in B lymphocytes. Intimate contact between B and T cells is important for the transfer of infectious virus from cell to cell ( Kaleta 1977), because MDV is highly cell-associated ( Schat 1984). ![]() 2.1, 6.2) to facilitate the transfer of virus. 1999) may be involved in attracting the activated T cells to the infected B cells (see Sects. Schat and Xing (2000) hypothesized recently that a viral homologue of interleukin (IL)-8 (vIL-8) ( LIu et al. Only activated, but not resting, T cells can be infected with MDV. The consequence of the lytic infection is that T lymphocytes become activated. The first phase is characterized by the replication of MDV in lymphoid cells, which are mostly B lymphocytes. Infection of chickens with MDV is characterized by several distinct phases in which innate and acquired immune responses play important roles. The pathogenesis of MD has been reviewed extensively ( Calnek 1986, Calnek 1998, Calnek 2000 Schat 1987b). Marek’s disease (MD), a herpesvirus-induced lymphomatous disease in chickens, has attracted the interest of immunologists since MD virus (MDV) was isolated in 1968 and vaccines became available shortly afterwards ( Witter 1985,Witter 2000). ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |